解剖学报

›› 2010, Vol. 41 ›› Issue (6): 872-875.doi: 10.3969/j.issn.0529-1356.2010.06.019

• 论著 • 上一篇    下一篇

糖尿病大鼠阴茎的氧化应激与阴茎勃起功能障碍的关系

刘丽2; 王文进1 ;朱浩1 ;李志宏2 ;丁文龙1*   

  1. 1.上海交通大学医学院解剖学教研室，上海 200025;2.上海健康职业技术学院解剖学教研室，上海 200237
  • 收稿日期:2010-06-17 修回日期:2010-08-11 出版日期:2010-12-06
  • 通讯作者: 丁文龙

Effect of oxidative stress on diabetic erectile dysfunction in rats

  1. 1. Department of Anatomy, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China；2.Department of Anatomy, Shanghai Health Vocational and Technical College，Shanghai 200237,China
  • Received:2010-06-17 Revised:2010-08-11 Online:2010-12-06
  • Contact: DING Wen-long

关键词: 糖尿病, 阴茎勃起功能障碍, 丙二醛, 总抗氧化能力, 核因子E2相关因子2, 硫代巴比妥酸比色法, 免疫印迹法, 大鼠

Abstract: Objective To investigate the effect of oxidative stress on diabetic erectile dysfunction( ED). Methods Diabetes mellitus(DM) was induced by streptozotocin (STZ) injection. Eight weeks and twelve weeks later, penis erectile function was detected by injecting apomorphine. The concentrations of malondialdehyde ( MDA) and total anti-oxygen capability (T-AOC) in penis were measured. Western blotting was used to measure nuclear factor E2related factor 2（Nrf2） in both control and diabetic rat penis tissues in present study. Results Compared with control group, the erection times of DM rats decreased significantly. The mean level of MDA in penis of DM rats were higher than that of control group（EM>P/EM>﹤0.01）, and the mean level of T-OC in DM rats was lower than that of control（EM>P/EM>﹤0.05）. Nrf2 protein expression decr

Key words: Diabetes mellitus, Erectile dysfunction, Malondialdehyde, Total anti-oxygen capability, Nuclear factor E2-related factor 2, TBA spectrophotometery, Western blotting, Rat 

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